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Faculty Profiles

Gyoonhee Han
  • Professor of Biotechnology
  • Senior Scientist, KRIBB, 2002-2004
  • Senior Scientist, Bayer RCK, 1999-2002
  • Postdoctotal Fellow, Johns Hopkins University, 1997-1999
  • Ph.D. in Organic Chemistry, Pennsylvania State University, 1997
  • M.S. in Medicinal Chemistry, Seoul National University, 1990
  • B.S. in Pharmacy, Seoul National University, 1988

Email: gyoonhee@yonsei.ac.kr
Tel: 02-2123-2882

Education

Pennsylvania State University: Aug. 1992 - June 1997
Department of Chemistry, Ph. D. in Chemistry Thesis Advisor: Professor Steven M. Weinreb “Development of New Amide Oxidation Methodology and Its Application to Enatioselective Total Synthesis of the Securinega Alkaloid: Approach to ()-8,9- Dihydro- norsecurinine and (-)-Norsecurinine”
 Seoul National University: March 1988 - Feb. 1990 College of Pharmacy, M.S. in Medicinal Chemistry Thesis Advisor: Professor Deukjoon Kim
 Seoul National University: March 1984 - Feb. 1988 College of Pharmacy, B.S. in Pharmacy

Courses and Current Research Areas

RESEARCH INTERESTS

Drug Discovery for Anti-cancer chemotheray and Anti-inflammatory Diseases
Computer aided Drug Design Lead Optimization by Medicinal Chemistry Optimization of Pysico-chemical Properties of the candidates Analysis of Metabolites Target Identification of New Therapeutic Chemicals

Selected Publications

Structure-Activity Relationship Studies of a Series of Novel δ-Lactam based Histone Deacetylase Inhibitors. Hwan Mook Kim, Dong-Kyu Ryu, Yongseok Choi, Bum Woo Park, Kiho Lee, Sang Bae Han, Chang-Woo Lee, Moo-Rim Kang, Jong Soon Kang, Shanthaveerappa K. Boovanahalli, Song-Kyu Park, Jung Whan Han, Tae-Gyu Chun, Hee-Yoon Lee, Ky-Youb Nam, Eun Hyun Choi, Gyoonhee Han, J. Med. Chem. 2007, 50, 2737-2741.

A facile synthesis of 2-acyl and 2-alkylbenzimidazoles for 5-lipoxygenase inhibitors. Jin Ha Lee, Mi Hyun Ahn, Eun Hyun Choi, Hea-Young Park Choo and Gyoonhee Han* Heterocycles, 2006, 70, 571-580.

Synthesis, enzymatic inhibition, and cancer cell growth inhibition of novel d-lactam-based histone deacetylase (HDAC) inhibitors. Hwan Mook Kim, Kiho Lee, Bum Woo Park, Dong Kyu Ryu, Kangjeon Kim, Chang Woo Lee, Song-Kyu Park, Jung Whan Han, Hee Yoon Lee, Hyun Yong Lee and Gyoonhee Han* Bioorg. Med. Chem. Lett. 2006, 16, 4068-4070.
TNF-alpha Converting Enzyme (TACE) Inhibitors from a Natural Source, Gelastatins and Their Hydroxamates: Synthesis, Biological Evaluation, Mechanism Studies, and Selectivity to alpha-Secretase. Song-Kyu Park, Sang Bae Han, Ki-Ho Lee, Song-Kyu Park, , Yung Hee Kho, Hyokon Chun, Ho Jae Lee, Choon-Whan Lee, Jae Young Yang, Yeo Dae Yoon, , Hwan Mook Kim, Hyun-Moo Choi, Hyun Seop Tae, Byung Gyu Kim, Hee-Yoon Lee, Ky-Youb Nam, Gyoonhee Han* Biochem. Biophy. Res. Comm. 2006, 341, 627-634.

Solid phase combinatorial synthesis of benzothiazoles and evaluation of topoisomerase II inhibitory activity. Suk-June Choi, Hyen Joo Park, Sang Kook Lee, Sang Woong Kim, Gyoonhee Han and Hea-Young Park Choo, Bioorg. Med. Chem. 2006, 14, 1229?1235.

More Information

PROFESSIONAL ACTIVITIES

March 2008 - present Yonsei University, Department of Biotechnology, Professor
Sep. 2004 - Feb. 2008 Yonsei University, Department of Biotechnology, Associate Professor
Feb. 2002 - Aug. 2004 Korea Research Institue of Bioscience and Biotechnology Senior Research ScientisImmunomodulator Research Lab.
Sept. 1999 - Feb. 2002 Bayer Research Center Kyoto, Senior Research Scientist “Development of New Chemical Entity for Asthma Therapy”
July 1997 - Aug. 1999 Johns Hopkins University, Department of Chemistry, Postdoctoral Fellow Research Advisor: Professor Gary H. Posner “Design, Development and Biological Evaluation of the Conceptually New Antiproliferative Analogs of 1?,25-dihydroxyvitamin D3”
March 1991 - June 1992 Korea Institute of Science and Technology (KIST) Commissioned Research Scientist

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