Underwood International College

Profile

College of Pharmacy, Yonsei University

Education

Mar. 1995 – Feb. 1999: Sungkyunkwan University (School of Pharmacy), B.S.

Mar. 1999 – Feb. 2001: Sungkyunkwan University (School of Pharmacy), M.S.

Aug. 2002 – Apr. 2007: University of Basel & Friedrich Miescher Institute for Biomedical Research (FMI), Switzerland (Department of Biochemistry), Ph.D.

Courses and Current Research Areas

COURSES

Biochemistry

Molecular Biology

Advacned Epigenetics

Specific topics of Biochemistry,

Specific topics of Molecular Biology

Specific topics of Signal Transduction

RESEARCH INTERESTS

1. Epigenetic regulation of protein complexes that modify chromatin and regulate          gene transcription (HDAC1/6/8, KMT1, KDM3/4/5, PRMTs, HP1, p53, DUBs)

2. Identification and validation of novel epigenetic therapeutic target and new small- molecule inhibitors for epigenetic regulators

3. Identifying the novel non-histone protein modifications that instruct chromatin organization and gene regulation (PTMs)

4. Elucidation of the chromatin code in tumorigenesis and cancer metabolism through chromatin dynamics and development of disease control technique (Cancer epigenetics).

Selected Publications

1. Jeon YH, Kim GW, Kim SY, Yi SA, Yoo J, Kim JY, Lee SW, Kwon SH*. Heterochromatin Protein 1: A Multiplayer in Cancer Progression. Cancers (Basel). 2022 Feb 1;14(3):763.
2. Lee DH, Kim GW, Yoo J, Lee SW, Jeon YH, Kim SY, Kang HG, Kim DH, Chun KH, Choi J, Kwon SH*. Histone demethylase KDM4C controls tumorigenesis of glioblastoma by epigenetically regulating p53 and c-Myc. Cell Death Dis. 2021 Jan 18;12(1):89.
3. Lee H, Hong Y, Kong G, Lee DH, Kim M, Tran Q, Cho H, Kim C, Park S, Kim SH, Kwon SH, Park J, Park J. Yin Yang 1 is required for PHD finger protein 20-mediated myogenic differentiation in vitro and in vivo. Cell Death Differ. 2020 Dec;27(12):3321-3336.
4. Yi SA, Lee DH, Kim GW, Ryu HW, Park JW, Lee J, Han J, Park JH, Oh H, Lee J, Choi J, Kim HS, Kang HG, Kim DH, Chun KH, You JS, Han JW*, Kwon SH*. HPV-mediated nuclear export of HP1γ drives cervical tumorigenesis by downregulation of p53. Cell Death Differ. 2020 Sep;27(9):2537-2551.
5. Lee DH, Kim GW, Jeon YH, Yoo J, Lee SW, Kwon SH*. Advances in histone demethylase KDM4 as cancer therapeutic targets. FASEB J. 2020 Mar;34(3):3461-3484.
6. Ryu HW, Shin DH, Lee DH, Choi J, Han G, Lee KY, Kwon SH*. HDAC6 deacetylates p53 at lysines 381/382 and differentially coordinates p53-induced apoptosis. Cancer Lett. 2017 Apr 10;391:162-171.
7. Lee JC, Kang SU, Jeon Y, Park JW, You JS, Ha SW, Bae N, Lubec G, Kwon SH, Lee JS, Cho EJ, Han JW. Regulation of p53 Activity by Protein L-Isoaspartyl Methyltransferase. Nat Commun. 2012 Jun 26;3:927.
8. Kwon SH, Workman JL. Heterochromatin Protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II. Genes Dev.  2010 Oct. 1; (24)19
9. Kwon SH, Zhang Y, Matthias P. The deacetylase HDAC6 is a novel essential component of stress granules involved in the stress response. Genes Dev. 2007 Dec 15;21(24):3381-94.
10. Kwon SH, Ahn SH, Kim YK, Bae GU, Yoon JW, Hong S, Lee HY, Lee YW, Lee HW, Han JW. Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells. J Biol Chem. 2002 Jan 18;277(3):2073-80