Underwood International College
Contents
Faculty Profiles
Yeun Kyu Jang
Email: ykjang@yonsei.ac.kr
Tel: 5654
[Key words: Histone code and chromatin regulation, Cancer epigenetics, Methyl proteome of nonhistone proteins and their cellular function]
- Associate Professor of Biology
- Ph.D. in Molecular Biology,?Seoul National University
- M.S. in Zoology, Seoul National University
- B.S. in Zoology, Seoul National University
Email: ykjang@yonsei.ac.kr
Tel: 5654
Profile
- 1995 - 1998: Postdoctoral Fellow, Dept. of Biochemistry and Biophysics, School of Medicine UNC-CH, USA
- 1998 - 2002: Instructor, School of Biological Sciences, Seoul National University
- 2000 - 2001 Cofounder and Scientific Director, Ambiogen
- 2002. 8 - 2005. 2: Principal Investigator, Lung Cancer Branch, Research Institute, National Cancer Center, Korea
- 2005. 3 - 2007.2.28: Chief & Principal Investigator, Carcinogenesis Branch, Research Institute, National Cancer Center, Korea
- 2007. 3.1-Present: Associate Professor, Department of Biology, Yonsei Univeristy
Education
- 1982-1986: Department of Zoology, Seoul National University (B.S.)
- 1987-1989: Department of Zoology, Seoul National University (M.S.)
- 1989-1995: Department of Molecular Biology, Seoul National University(Ph.D.)
Courses and Current Research Areas
Our research is focused on understanding the links between signaling, chromatin dynamics, and gene regulation in eukaryotic model systems such as yeast and humans. In eukaryotes, DNA binds with basic histone proteins to form higher ordered chromatin structure. The proper assembly and maintenance of chromatin are critical for survival of all eukaryotes. The amino-terminal tails of core histone proteins are chemically modified by acetylation, methylation and phosphorylation. The modifications result in changes in chromatin structure, in turn which can influence gene expression and heterochromatic stability. The study of chromatin structure and function related to gene expression, DNA replication, and repair is called ‘Epigenetics’. Histone modifications and DNA methylation involved in changes in chromatin structure are termed ‘epigenetic code’. At present, this epigenetic code is considered as a key word critical to solve the mystery related to stem cell differentiation, cell type specificity, and cancer development. Our research goal is to understand the role of histone code in chromatin modification and gene expression at the cellular and molecular levels. In particular, we would like to study carcinogenesis by analyzing the function of histone methyltransferases and histone demethylases which are essential for creation and erasure of epigenetic code.
In addition, we are interested in lysine or/and arginine methylations of nonhistone proteins which are involved in diverse cellular functions such as carcinogenesis, apoptosis, DNA repair, or transcription etc. Moreover, we are currently doing research project for discovery and development of anti-cancer drugs having inhibitory activities against histone-modifying enzymes.
In addition, we are interested in lysine or/and arginine methylations of nonhistone proteins which are involved in diverse cellular functions such as carcinogenesis, apoptosis, DNA repair, or transcription etc. Moreover, we are currently doing research project for discovery and development of anti-cancer drugs having inhibitory activities against histone-modifying enzymes.
[Key words: Histone code and chromatin regulation, Cancer epigenetics, Methyl proteome of nonhistone proteins and their cellular function]
Selected Publications
- Hyun Soo Kim, Dong Keun Rhee and Yeun Kyu Jang* (*Corresponding author), 2008. Methylations of histone H3 lysine 9 and lysine 36 are functionally linked to DNA replication checkpoint control in fission yeast. Biochemical and Biophysical Research Communications 368(2) : 419 - 425
- Kyong-Ah Yoon, Bin Hwangbo, Il-Jin Kim, Sohee Park, Hee Sun Kim, Hyun Jung Kee, Jong Eun Lee, Yeun Kyu Jang, Jae-Gahb Park and Jin Soo Lee, 2006. Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer. Carcinogenesis 27(11) : 2217 - 2222
- Eun Shik Choi, Jin A Shin, Hyun Soo Kim, and Yeun Kyu Jang* (*Corresponding author), 2005. Dynamic regulation of replication independent deposition of histone H3 in fission yeast. Nucleic Acids Res. 33(22) : 7102 - 7110
- Shin, Jin A, Eun Shik Choi, Hyun Soo Kim, Jenny Ho, Felicity Watts, Sang Dai Park, and Yeun Kyu Jang* (*Corresponding author), 2005. SUMO Modification Is Involved in the Maintenance of Heterochromatin Stability in Fission Yeast. Molecular Cell 19(6) : 817 - 828
- Kim, Hyun Soo, Eun Shik Choi, Jin A Shin, Yeun Kyu Jang*, & Sang Dai Park (*Corresponding author), 2004. Regulation of Swi6/HP1-dependent heterochromatin assembly by cooperation of components of the mitogen-activated protein kinase pathway and a histone deacetylase Clr6. J. Biol. Chem. 279() : 42850 - 42859
- Choi, Eun Shik, Hyun Soo Kim, Yeun Kyu Jang,* and Sang Dai Park* [*co-corresponding authors] , 2002. Two ubiquitin-conjugating enzymes, Rhp6 and UbcX, regulate heterochromatin silencing in Schizosaccharomyces pombe. Mol. Cell. Biol. 22(23) : 8366 - 8374
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Underwood International College, Yonsei University 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722 Republic of Korea
Copyright © 2017 Yonsei Underwood International College. All rights reserved.
Underwood International College, Yonsei University 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722 Republic of Korea
Copyright © 2017 Yonsei Underwood International College. All rights reserved.
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