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Faculty Profiles

S. Carroll Brooks III
Chair of Life Science and Biotechnology


  • Associate Professor of Life Science and Biotechnology
  • Ph.D. in Environmental Toxicology, Cornell University
  • B.A. in Chemistry, Wayne State University

Email: brookssc@yonsei.ac.kr
Tel: 02-2123-5661

Profile

S. Carroll Brooks III has formal academic training in several fields including chemistry, biochemistry, environmental toxicology, cellular/molecular biology, and developmental biology. In addition, he has industrial training in the fields of chemical toxicology and environmental virology. His research experience includes work in both academic and industrial laboratories. As a tenured Associate Professor of Chemistry at Brevard College in North Carolina, his teaching responsibilities included lecture and laboratory courses in General Chemistry, Organic Chemistry, Biochemistry, and Environmental Chemistry. As a certified 9-12 General Science educator in North Carolina, he directed the Teacher Education licensure program in General Science. In addition, he served as an Adjunct Assistant Professor of Medicine at Duke University researching osteoarthritis. During his sabbatical leave, his research focused on metabolic and inflammatory diseases of the liver. He also taught graduate courses in Biochemical and Molecular Pharmacology in the College of Pharmacy at Seoul National University in South Korea. He joined Yonsei University in the fall of 2009. 
 
Sabbatical, Seoul National University, Seoul, South Korea, 2008-2009
Associate Professor (tenured) Brevard College, Brevard, NC, 2007-2009
Adjunct Assistant Professor, Duke University, Durham, NC, 2004-2009
Assistant Professor, Brevard College, Brevard, NC, 2001-2007
Assistant Professor, Mars Hill College, Mars Hill, NC, 2000-2001
Postdoctoral Research Associate, Cornell University, Ithaca, NY, 1999-2000
Director of Virology, Environmental Associates, Ithaca, NY, 1997-1999
Research Assistant, Institute of Chemical Toxicology, Detroit, MI, 1990-1992

Education

  • Ph.D. Environmental Toxicology, Cornell University
  • B.A. Chemistry, Wayne State University

Courses and Current Research Areas

Courses

LST3202-01 Environmental Toxicology
LSB3101-04 Biochemistry (1)
BTE2201-02 Organic Chemistry (2)
LST4002-01 Cancer Biology
BIO3714-01 Analysis in Ecotoxicology
LST3206-01 Developmental Biology
BTE2200-02 Organic Chemistry (1)
LST4003-01 Cancer Development
BCH3119-01 Analysis in the Biology of Cancer Development
LST4001-01 Senior Independent Study
UIC 1920-01 Science in Context

IEE1111-01 General Chemistry

Research

  • Seoul National University, College of Pharmacy, Department of Pharmacology Molecular pharmacology of dithiolethiones, 2008-2009.

  • Duke University Medical School, Analysis of human serum and urine for the presence of biomarkers of osteoarthritis including procollagen II C-propeptide (CPII), cellular oligomeric matrix protein (COMP), hyaluronic acid (HA), cross-linked N-telopeptide of type I collagen (NTx-I), cross-linked C-telopeptide of type II collagen (CTx-II), and creatinine (Cr), Summer 2007.

  • Duke University Medical School, Development of a hexuronic acid assay for the quantification of uronic acids in syovial fluid, Summer 2006.

  • Duke University Medical School, The creation and use of Vitamin C-Prodrugs to augment the cellular uptake of a bisphosphonate and an ApoE peptide into primary human chondrocytes, Summer 2005.

  • Duke University Medical School, Generation of collagen IIalpha1 (COL2A1) mutant proteins which are resistant to cleavage by matrix metalloproteinase 13 (MMP-13), Summer 2004.

  • Cornell University, Department of Nutritional Sciences Generation of genetic knockouts of the heparan sulfate proteoglycan syndecan-4, 1999-2000.

  • Cornell University, Department of Veterinary Pathology Retinoid-induced differentiation and growth arrest of human leukemia cells, 1992-1997.

  • Wayne State University, Institute of Chemical Toxicology Induction of rat hepatic and renal P-450 monoxygenases by nitrogen heterocycles, 1990-1992.

Selected Publications

  • Lee,W.H.,Kim,Y.W.,Choi,J.H.,BrooksIII,S.C.,Lee,M.O.and Kim,S.G.2009. Oltipraz and dithiolethione congeners inhibit hypoxia inducible factor-1alpha activity through S6K1 inhibition and hydrogen peroxide-scavenging effect. Molecular Cancer Therapeutics, 8(10): 2791-802
  • BrooksIII,S.C.,Brooks,J.S.,Lee,W.H.,Lee,M.G.and Kim,S.G. 2009. Therapeutic potential of dithiolethiones for hepatic diseases. Pharmacology & Therapeutics. 124(1): 31-43
  • Cho,I.J.,Ki,S.W.,BrooksIII,S.C.,and Kim,S.G.2009. Role of hepatitis B virus X repression of C/EBPbeta activity in the down-regulation of glutathione S-transferase A2 gene: Implications in other phase II detoxifying enzyme expression. Xenobiotica, 39(2): 182-192
  • Seifer,D.R.,Furman,B.D.,Guilak,F.,Olson,S.A.,BrooksIII,S.C.,and Kraus,V.B.2008.Novel synovial fluid recovery method allows for quantification of inflammatory markers of arthritis in mice. Osteoarthritis and Cartilage 16: 1532-1538
  • Platko,J.D.,Forbes,M.E.,Varvayanis S.,Williams,M.N.,BrooksIII,S.C.,Cherington,V.,and Yen,A. 1998. Polyoma Middle T Antigen in HL-60 Cells Accelerates Hematopoietic Myeloid and Monocytic Cell Differentiation. Experimental Cell Research 238: 42-50
  • BrooksIII,S.Carroll.January, 1998. Retinoid-induced differentiation and growth arrest of human acute myelogenous leukemia cells. Doctoral dissertation, Cornell University
  • BrooksIII,S.C.,Sturgill,R.S.,Choi,J.,and Yen, A. 1997. An RXR-selective analog attenuates the RARalpha-selective analog-induced differentiation and non-G1-restricted growth arrest of NB4 cells. Experimental Cell Research 234: 259-269
  • BrooksIII,S.C.,Kazmer,S.,Levin, A.A.,and Yen,A. 1996. Myeloid differentiation and RB phosphorylation changes in HL-60 cells induced by RAR- and RXR-selective retinoic acid analogs. Blood 87: 227-237.

More Information

  • Sabbatical, Seoul National University, Seoul, South Korea, 2008-2009
  • Associate Professor (tenured) Brevard College, Brevard, NC, 2007-2009
  • Adjunct Assistant Professor, Duke University, Durham, NC, 2004-2009
  • Assistant Professor, Brevard College, Brevard, NC, 2001-2007
  • Assistant Professor, Mars Hill College, Mars Hill, NC, 2000-2001
  • Postdoctoral Research Associate, Cornell University, Ithaca, NY, 1999-2000
  • Director of Virology, Environmental Associates, Ithaca, NY, 1997-1999
  • Research Assistant, Institute of Chemical Toxicology, Detroit, MI, 1990-1992

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